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Brighton & Sussex Medical School

Publications

Publications

The latest and historical publications from the Brighton and Sussex CTU.

2024

  • HiFlo (Results) Kapur A, Rojas-Anaya H, Roberts G, Roland D, Gupta A, Lazner M, Bayreuther J, Cantle F, Jones C, Pappachan J, Bremner S, James D, Fitzgerald S, Owens K, Asim L, Khaleva E, Seddon P. High-flow humidified oxygen as an early intervention in children with acute severe asthma: a feasibility randomised controlled trial ERJ Open Res. 2024 Oct 7;10(5):00168-2024. doi: 10.1183/23120541.00168-2024. eCollection 2024 Sep.PMID: 39377094. Read it here >

  • HiFlo (Protocol) Rojas-Anaya H, Kapur A, Roberts G, Roland D, Gupta A, Lazner M, Bayreuther J, Pappachan J, Jones C, Bremner S, Cantle F, Seddon P. High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial JMIR Res Protoc. 2024 Mar 28;13:e54081. doi: 10.2196/54081.PMID: 38546733. Read it here >

  • HYVET2 (Results) Mensah E, Ali K, Okorie M, Bremner S, McAlister C, Perry N, Rajkumar C. Exploring the Challenges of Recruiting Older People for a Randomised Trial Assessing the Feasibility of Treating White Coat Hypertension in the UK General Practices: A Mixed-methods study Curr Hypertens Rev. 2024 Aug 19. doi: 10.2174/0115734021299574240809114921. Online ahead of print.PMID: 39162278. Read it here >

  • PWA (Results)Dunn A, Alvarez J, Arbon A, Bremner S, Elsby-Pearson C, Emsley R, Jones C, Lawrence P, Lester KJ, Morson N, Perry N, Simner J, Thomson A, Cartwright-Hatton S. Investigating the effect of providing monetary incentives to participants on completion rates of referred co-respondents: An embedded randomized controlled trial. Contemp Clin Trials Commun. 2024 Feb 8;38:101267. doi: 10.1016/j.conctc.2024.101267. PMID: 38419810; PMCID: PMC10899055. Read it here >

  • PWA (Results) Dunn A, Alvarez J, Arbon A, Bremner S, Elsby-Pearson C, Emsley R, Jones C, Lawrence P, Lester KJ, Morson N, Simner J, Thomson A, Cartwright-Hatton S. Effectiveness of an unguided modular online intervention for highly anxious parents in preventing anxiety in their children: a parallel group randomised controlled trial Lancet Reg Health Eur. 2024 Sep 4;45:101038. doi: 10.1016/j.lanepe.2024.101038. eCollection 2024 Oct.PMID: 39291249. Read it here >

2023

  • GIVE3 (Protocol) Hayward M, Berry K, Bremner S, Cavanagh K, Dodgson G, Fowler D, Gage H, Greenwood K, Hazell C, Bibby-Jones AM, Robertson S, Touray M, Dailey N, Strauss C. Increasing access to CBT for psychosis patients: study protocol for a randomised controlled trial evaluating brief, targeted CBT for distressing voices delivered by assistant psychologists (GiVE3). Trials. 2023 Sep 15;24(1):588. doi: 10.1186/s13063-023-07611-7. PMID: 37715255; PMCID -07611-7. PMID. Read it here >

  • Hepmarc (Results) Bradshaw D, Abramowicz I, Bremner S, Verma S, Gilleece Y, Kirk S, Nelson M, Housman R, Miras H, Orkin C, Fox A, Curnock M, Jennings L, Gompels M, Clarke E, Robinson R, Lambert P, Chadwick D, Perry N. Hepmarc: A 96 week randomised controlled feasibility trial of addon maraviroc in people with HIV and non-alcoholic fatty liver disease. PLoS One. 2023 Jul 14;18(7):e0288598. doi: 10.1371/journal.pone.0288598. PMID: 37450478; PMCID: PMC10348519. Read it here >

  • LIGHTMind Strauss C, Bibby-Jones A, Jones F, et al. Clinical Effectiveness and Cost-Effectiveness of Supported Mindfulness-Based Cognitive Therapy Self-help Compared With Supported Cognitive Behavioral Therapy Self-help for Adults Experiencing Depression: The LowIntensity Guided Help Through Mindfulness (LIGHTMind) Randomized Clinical Trial. JAMA Psychiatry. 2023;80(5):415–424. doi:10.1001/jamapsychiatry.2023.0222. Read it here >

  • PWA (Protocol) Dunn A, Alvarez J, Arbon A, Bremner S, Elsby-Pearson C, Emsley R, Jones C, Lawrence P, Lester KJ, Majdandžić M, Morson N, Perry N, Simner J, Cartwright-Hatton S, Thomson A. Investigating the effect of providing monetary incentives to participants on completion rates of referred co-respondents: An embedded randomized controlled trial. Study within a trial (SWAT) protocol. Contemp Clin Trials Commun. 2023 Feb 14;32:101090. doi: 10.1016/j.conctc.2023.101090. PMID: 36865678; PMCID: PMC9971523. Read it here >

  • Wrapped (Protocol) Newby K, Kwah K, Schumacher L, Crutzen R, Bailey J, Jackson L, Bremner S, Brown K. An Intervention to Increase Condom Use Among Users of Sexually Transmitted Infection Self-sampling Websites (Wrapped): Protocol for a Randomized Controlled Feasibility Trial JMIR Res Protoc 2023;12:e43645 DOI: 10.2196/43645. Read it here >

2022

  • HIS-UK (Protocol) Stone N, Bedford R, Newby K, Brown K, Jackson L, Bremner S, Morrison L, McGrath N, Nadarzynski T, Bayley J, Perry N, Graham C. Reducing New Chlamydia Infection Among Young Men by Promoting Correct and Consistent Condom Use: Protocol for a Randomized Controlled Trial JMIR Res Protoc 2022;11(8):e35729. Read it here >

  • PWA (Protocol) Dunn A, Alvarez J, Arbon A, Bremner S, Elsby-Pearson C, Emsley R, Jones C, Lawrence P, Lester KJ, Majdandžić M, Morson N, Perry N, Simner J, Thomson A, Cartwright-Hatton S. Effectiveness of a Web-Based Intervention to Prevent Anxiety in the Children of Parents With Anxiety: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2022 Nov 10;11(11):e40707. doi: 10.2196/40707. PMID: 36355406; PMCID: PMC9693706. Read it here >
BACKGROUND IMAGE FOR PANEL

2020

Hepmarc (Protocol) Bradshaw D, Gilleece Y, Verma S, Abramowicz I, Bremner S, Perry N. Protocol for a phase IV, open-label feasibility study investigating non-invasive markers of hepatic fibrosis in people living with HIV-1 and non-alcoholic fatty liver disease randomised to receiving optimised background therapy (OBT) plus maraviroc or OBT alone. BMJ Open. 2020 Jul 6;10(7):e035596. doi: 10.1136/bmjopen-2019-035596. PMID: 32636281; PMCID: PMC7342479. Read it here >

PIBIK (Protocol) Iwuji CC, Churchill D, Bremner S, Perry N, To Y, Lambert D, Bruce C, Waters L, Orkin C, Geretti AM. A phase IV randomised, open-label pilot study to evaluate switching from proteaseinhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial. BMC Infect Dis. 2020 Jul 20;20(1):524. doi: 10.1186/s12879-020-05240-y. PMID: 32689975; PMCID: PMC7370264. Read it here >

Reduce (Results) Macken L, Bremner S, Gage H, Touray M, Williams P, Crook D, Mason L, Lambert D, Evans CJ, Cooper M, Timeyin J, Steer S, Austin M, Parnell N, Thomson SJ, Sheridan D, Wright M, Isaacs P, Hashim A, Verma S. Randomised clinical trial: palliative long-term abdominal drains vs large-volume paracentesis in refractory ascites due to cirrhosis. Aliment Pharmacol Ther. 2020 Jul;52(1):107-122. doi: 10.1111/apt.15802. Epub 2020 Jun 1. PMID: 32478917. Read it here >

Reduce (Results) Cooper M, Pollard A, Pandey A, Bremner S, Macken L, Evans CJ, Austin M, Parnell N, Steer S, Thomson S, Hashim A, Mason L, Verma S. Palliative Long-Term Abdominal Drains Versus Large Volume Paracentesis in Refractory Ascites Due to Cirrhosis (REDUCe Study): Qualitative Outcomes. J Pain Symptom Manage. 2021 Aug;62(2):312-325.e2. doi: 10.1016/j.jpainsymman.2020.12.007. Epub 2020 Dec 19. PMID: 33348031. Read it here >

BACKGROUND IMAGE FOR PANEL

2019

  • HYVET2 (Protocol) Okorie M, Ali K, Bremner S, Beckett N, Jackson S, Quirk R, McAlister C, Perry N, Potter J, Bulpitt C, Rajkumar C. Treatment of White Coat HYpertension in the Very Elderly Trial (HYVET 2) - Feasibility of a Randomized Controlled Trial (Study Protocol). Artery Res 25, 19–25 (2019). https://doi.org/10.2991/artres.k.191106.001. Read it here >

  • RIIiO (Results) Kümin M, Deery J, Turney S, Price C, Vinayakam P, Smith A, Filippa A, Wilkinson-Guy L, Moore F, O'Sullivan M, Dunbar M, Gaylard J, Newman J, Harper CM, Minney D, Parkin C, Mew L, Pearce O, Third K, Shirley H, Reed M, Jefferies L, Hewitt-Gray J, Scarborough C, Lambert D, Jones CI, Bremner S, Fatz D, Perry N, Costa M, Scarborough M. Reducing Implant Infection in Orthopaedics (RIIiO): Results of a pilot study comparing the influence of forced air and resistive fabric warming technologies on postoperative infections following orthopaedic implant surgery. J Hosp Infect. 2019 Dec;103(4):412-419. doi: 10.1016/j.jhin.2019.08.019. Epub 2019 Sep 4. PMID: 31493477. Read it here >

2018

  • Reduce (Protocol) Macken L, Mason L, Evans C, Gage H, Jordan J, Austin M, Parnell N, Cooper M, Steer S, Boles J, Bremner S, Lambert D, Crook D, Earl G, Timeyin J, Verma S. Palliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis: study protocol for a feasibility randomised controlled trial. Trials. 2018 Jul 27;19(1):401. doi: 10.1186/s13063-018-2779-0. Erratum in: Trials. 2018 Sep 13;19(1):488. doi: 10.1186/s13063-018-2883-1. PMID: 30053891; PMCID: PMC6062920. Read it here >

  • RIIiO (Protocol) Kümin M, Harper CM, Reed M, Bremner S, Perry N, Scarborough M. Reducing Implant Infection in Orthopaedics (RIIiO): a pilot study for a randomised controlled trial comparing the influence of forced air versus resistive fabric warming technologies on postoperative infection rates following orthopaedic implant surgery in adults. Trials. 2018 Nov 19;19(1):640. doi: 10.1186/s13063-018-3011-y. PMID: 30454034; PMCID: PMC6245696. Read it here >
BACKGROUND IMAGE FOR PANEL

2016

  • OPSAL (Protocol) Mukhopadhyay S, Seddon P, Earl G, Wileman E, Symes L, Olden C, Alberti C, Bremner S, Lansley A, Palmer CN, Beydon N. How can we optimise inhaled beta2 agonist dose as 'reliever' medicine for wheezy pre-school children? Study protocol for a randomised controlled trial. Trials. 2016 Nov 11;17(1):541. doi: 10.1186/s13063-016-1437-7. PMID: 27836009; PMCID: PMC5106800. Read it here >