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Professor Martin Llewelyn

Professor Martin Llewelyn (BSc, FRCP, DTMH, PhD)

Professor in Infectious Diseases
E: M.J.Llewelyn@bsms.ac.uk
T: +44 (0)1273 876671
Location: Medical Research Building, Room 1.08, BSMS, University of Sussex, BN1 9PS

DA: Debbie Miller
T: +44 (0)1273 877890
E: d.miller@bsms.ac.uk

Areas of expertise: Healthcare associated infection; antimicrobial resistance

Research areas: Infection and immunology

Biography

Prof Martin Llewelyn has worked at BSMS since 2004 and holds an honorary contract at Brighton and Sussex University Hospitals NHS Trust as a Consultant in Infectious Diseases. He did his Undergraduate medical training at the Royal London Hospital graduating in 1992. After Medical House-Officer and Senior House Officer posts in North East London he undertook higher specialist training in Infectious Diseases and General Internal Medicine in North Thames. He spent three years on an MRC-funded research training fellowship at Imperial College studying host immune responses to bacterial superantigen toxins. He obtained his CCT and PhD in 2004.

Research

Martin’s research is focused on the common, life-threatening infections which affect patients in the NHS, in particular on healthcare associated and antibiotic resistant pathogens such as Staphylococcus aureus and Clostridium difficile. Major current themes of his research are application of microbial genome sequencing to the study of transmission and pathogenesis of S. aureus infection and reducing antibiotic usage in hospital through optimising treatment strategies. Martin’s research is undertaken in collaboration with groups such as Modernising Medical Microbiology, the International Staphylococcus Aureus Collaboration and the NIHR-funded Antibiotic Reduction and Conservation in Hospitals (ARK-Hospital) programme.

Teaching

Martin teaches extensively on the Undergraduate Course at BSMS in Clinical Infectious Diseases, Microbiology and Immunology. In the first term of Year 1 ‘Foundations of Health and Disease’ he teaches basic microbiology and about the role of the host and pathogen in the outcome of infection. In Year 3 he teaches about the scientific basis of infectious diseases and the immune response to infection. In the Fourth Year specialist rotation in infectious diseases he teaches the diagnosis and management of common infectious diseases. Each year Martin supervises medical students undertaking both clinical and laboratory based individual research projects.

Selected publications

Hamilton WL, Pires SM, Lippett S, Gudka V, Cross ELA, Llewelyn MJ. The impactof diagnostic microbiology on de-escalation of antimicrobial therapy inhospitalised adults. BMC Infect Dis. 2020 Feb 3;20(1):102. doi:10.1186/s12879-020-4823-4. PMID: 32013908; PMCID: PMC6998081.

Stoneham S, Schilling W, San Francisco A, Llewelyn MJ. Twelve year analysis ofaerobic-only blood cultures for routine detection of bacteraemia. J Hosp Infect.2020 Apr;104(4):592-596. doi: 10.1016/j.jhin.2019.11.025. Epub 2019 Dec 3. PMID:31809776.

Peto L, Fawcett NJ, Crook DW, Peto TEA, Llewelyn MJ, Walker AS. Selectiveculture enrichment and sequencing of feces to enhance detection of antimicrobialresistance genes in third-generation cephalosporin resistant Enterobacteriaceae.PLoS One. 2019 Nov 8;14(11):e0222831. doi: 10.1371/journal.pone.0222831. PMID:31703058; PMCID: PMC6839868.

Schweitzer VA, van Werkhoven CH, Rodríguez Baño J, Bielicki J, Harbarth S,Hulscher M, Huttner B, Islam J, Little P, Pulcini C, Savoldi A, Tacconelli E,Timsit JF, van Smeden M, Wolkewitz M, Bonten MJM, Walker AS, Llewelyn MJ; JointProgramming Initiative on Antimicrobial Resistance (JPIAMR) Working Group onDesign of Antimicrobial Stewardship Evaluations. Optimizing design of researchto evaluate antibiotic stewardship interventions: consensus recommendations of amultinational working group. Clin Microbiol Infect. 2020 Jan;26(1):41-50. doi:10.1016/j.cmi.2019.08.017. Epub 2019 Sep 4. PMID: 31493472.

Cross ELA, Sivyer K, Islam J, Santillo M, Mowbray F, Peto TEA, Walker AS,Yardley L, Llewelyn MJ. Adaptation and implementation of the ARK (AntibioticReview Kit) intervention to safely and substantially reduce antibiotic use inhospitals: a feasibility study. J Hosp Infect. 2019 Nov;103(3):268-275. doi:10.1016/j.jhin.2019.07.017. Epub 2019 Aug 5. PMID: 31394146.

Walker AS, Budgell E, Laskawiec-Szkonter M, Sivyer K, Wordsworth S, Quaddy J,Santillo M, Krusche A, Roope LSJ, Bright N, Mowbray F, Jones N, Hand K, RahmanN, Dobson M, Hedley E, Crook D, Sharland M, Roseveare C, Hobbs FDR, Butler C,Vaughan L, Hopkins S, Yardley L, Peto TEA, Llewelyn MJ; ARK trial team.Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for astepped-wedge cluster-randomised controlled trial. Trials. 2019 Jul11;20(1):421. doi: 10.1186/s13063-019-3497-y. PMID: 31296255; PMCID: PMC6625068.

Pouwels KB, Hopkins S, Llewelyn MJ, Walker AS, McNulty CA, Robotham JV.Duration of antibiotic treatment for common infections in English primary care:cross sectional analysis and comparison with guidelines. BMJ. 2019 Feb27;364:l440. doi: 10.1136/bmj.l440. PMID: 30814052; PMCID: PMC6391655.

Schweitzer VA, van Heijl I, van Werkhoven CH, Islam J, Hendriks-Spoor KD,Bielicki J, Bonten MJM, Walker AS, Llewelyn MJ; Consensus on AntimicrobialStewardship Evaluations (CASE) study group. The quality of studies evaluatingantimicrobial stewardship interventions: a systematic review. Clin MicrobiolInfect. 2019 May;25(5):555-561. doi: 10.1016/j.cmi.2018.11.002. Epub 2018 Nov23. PMID: 30472426.

Vihta KD, Stoesser N, Llewelyn MJ, Quan TP, Davies T, Fawcett NJ, Dunn L,Jeffery K, Butler CC, Hayward G, Andersson M, Morgan M, Oakley S, Mason A,Hopkins S, Wyllie DH, Crook DW, Wilcox MH, Johnson AP, Peto TEA, Walker AS.Trends over time in Escherichia coli bloodstream infections, urinary tractinfections, and antibiotic susceptibilities in Oxfordshire, UK, 1998-2016: astudy of electronic health records. Lancet Infect Dis. 2018Oct;18(10):1138-1149. doi: 10.1016/S1473-3099(18)30353-0. Epub 2018 Aug 17.PMID: 30126643.

Onakpoya IJ, Walker AS, Tan PS, Spencer EA, Gbinigie OA, Cook J, Llewelyn MJ,Butler CC. Overview of systematic reviews assessing the evidence for shorterversus longer duration antibiotic treatment for bacterial infections in secondarycare. PLoS One. 2018 Mar 28;13(3):e0194858. doi: 10.1371/journal.pone.0194858.eCollection 2018. Review. PubMed PMID: 29590188; PubMed Central PMCID:PMC5874047.

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